EyeWorld Korea March 2018 Issue

March 2018 EWAP FEATURE 23 배양 조직을 이식한 토끼 각막(배양 조직을 이식한 EK 그룹)에서 이식 4일 후 각막이 1,000 µm까지 두꺼워졌다. 3주 후에는 400 µm 미만으로 회복되었다. 각막 내피세포 주사를 맞은 토끼 각막의 경 우, 수술 4일 후 각막이 약간 두꺼워졌지만 3주 후에는 500 µm 미만으로 점차 회복되었다. 토끼의 최종 각막 두께는 400 µm~425 µm 사이로 조절하였으며, 항인체 핵항체 염색 시 교차 반응을 보이 지 않았다. Source: Jodhbir Mehta, MD 한 실험에서 더 좋은 결과를 보였다고 말했다. 16 EWAP References 1. Terry MA. Endothelial keratoplasty: history, current state, and future directions. Cornea . 2006;25:873–8. 2. Gain P, et al. Global survey of corneal transplantation and eye banking. JAMA Ophthalmol . 2016;134:167–73. 3. Agarwal A, et al. Pre-Descemet endothelial keratoplasty with infant donor corneas: a prospective analysis. Cornea. 2015;34:859–65. 4. Agarwal A. Pre-Descemet’s endothelial keratoplasty (PDEK). New Delhi, India. Jaypee Brothers Medical Publishers. November 2017. 5. Balachandran C, et al. Spontaneous corneal clearance despite graft detachment in Descemet membrane endothelial keratoplasty. Am J Ophthalmol. 2009;148:227–234. 6. Arbelaez JG, et al. Long-term follow-up and complications of stripping Descemet membrane without placement of graft in eyes with Fuchs’ endothelial dystrophy. Cornea. 2014;33:1295–9. 7. Koenig SB. Planned Descemetorhexis without endothelial keratoplasty in eyes with Fuchs’ corneal endothelial dystrophy. Cornea. 2015;34:1149–51. 8. Okumara N, et al. Effect of the rho- associated kinase inhibitor eye drop (ripasudil) on corneal endothelial wound healing. Invest Ophthalmol Vis Sci. 2016;57:1284–92. 9. Borkar DS, et al. Treatment of Fuchs’ endothelial dystrophy by Descemet stripping without endothelial keratoplasty. Cornea. 2016;35:1267–73. 10. Moloney G, et al. Descemetorhexis for Fuchs’ dystrophy. Can J Ophthalmol. 2015;50:68–72. 11. Moloney G, et al. Descemetorhexis without grafting for Fuchs’ endothelial dystrophy–supplementation with topical ripasudil. Cornea. 2017;36:642–648. 12. Peh GS, et al. Cultivation of human corneal endothelial cells isolated from paired donor corneas. PLoS One. 2011;6:e28310. 13. Numata R, et al. Cultivation of corneal endothelial cells on a pericellular matrix prepared from human decidua- derived mesenchymal cells. PLoS One. 2014;9:e88169. 14. Mimura T, et al. Treatment of rabbit bullous keratopathy with precursors derived from cultured human corneal endothelium. Invest Ophthalmol Vis Sci. 2005;46:3637–44. 15. Tan T, Peh GS, George BL, Cajucom- Uy HY, Dong D, Finkelstein EA, Mehta JS. A cost-minimization analysis of tissue-engineered constructs for corneal endothelium transplantation. PLoS One. 2014;9(6). 16. Bhogal M, Lwin CN, Seah XY, Peh G, Mehta JS. Allogeneic descement’s membrane transplantation (DMT) enhances endothelial monolayer formation and restores functional integrity following descemet’s stripping. Invest Ophthalmol Vis Sci. 2017. Editors’ note: Dr. Mehta has a patent on the culture media used for cultivation of human corneal endothelial cells. Dr. Agarwal and Dr. Colby have no financial interests related to their comments. Contact information Agarwal: dragarwal@vsnl.com Colby: kcolby@bsd.uchicago.edu Mehta: jodmehta@gmail.com