EyeWorld Asia-Pacific March 2012 Issue

33 EW CATARACT/IOL March 2012 What we know, what we don’t know, and what we can do about it I t’s always concerning to hear surgeons say, “I don’t know; it’s a mystery,” when speaking about a medical phenomenon. Physicians live and breathe facts and data on who develops a condition and why and what can be done to treat it. But with negative dysphotopsia, the answers to many of those questions are puzzling. “We don’t really know what it is, and we don’t understand it very well,” said James Davison, MD , cataract and refractive specialist, Wolfe Eye Clinic, locations throughout Iowa, USA. “It only seems to happen in people who have perfect surgery. Everything else looks absolutely perfect and then they have this difficulty.” This difficulty, or negative dysphotopsia (ND), comes in the form of a black line, a parenthesis out of the patient’s peripheral vision often described as a dark shadow. “The typical thing they will say is to envision a horse with blinders,” said Samuel Masket, MD , clinical professor of ophthalmology, Jules Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, Calif., USA. “That’s what it looks like to them. They can’t see to the side.” What causes ND? The maddening thing about ND is doctors haven’t been able to nail down why this phenomenon happens or to whom it will happen. There are plenty of theories about what causes ND and what to do about it, but not much has been proven clinically. Different physicians have different stories. For example, Kevin Miller, MD , professor of clinical ophthalmology, Jules Stein Eye Institute, believes ND is directly related to the square-edge shape of the implanted IOL. “It has something to do with the square edge,” said Dr. Miller. “With rounded-edge lenses, no one ever complained about this kind of thing.” Dr. Miller believes ND occurs because light coming into the pupil from the temporal field of vision causes the problem. When light hits the square edge of the IOL on the nasal side of the optic, the edge acts like a plano mirror, reflecting light off the edge. This light then bounces back to the temporal side of the retina, causing one of several positive dysphotopsias, and doesn’t get through the edge to illuminate a patch of nasal retina, thus casting an arc-shaped shadow over the area. He explained this theory in the August 2005 issue of the Journal of Cataract & Refractive Surgery ( JCRS 31:1488-1489). “The interesting thing is we started seeing this with the square- edge silicon lenses, although it wasn’t as bad with the silicon as it was with acrylic,” he said. “So it has something to do with the square edge and a little bit to do with the material.” Likewise, Dr. Davison believes ND is lens-shape related, although he’s unable to pinpoint precisely why. “I think it has something to do with the shape of the lens we Uncovering the mystery of negative dysphotopsia by Faith A. Hayden EyeWorld Staff Writer put in the eye versus the shape of the lens we take out,” he said. “I think we probably saw things like this before the square edge, but the square edges seem to make for more frequent complaints. There might be some internal reflections; there might be some sort of edge effect. Some papers show that you can still have ND even if you put in a round-edge IOL.” Dr. Masket, on the other hand, believes ND is generated from the overlap of the anterior capsulorhexis onto the anterior surface of the IOL. He wrote about this and the surgical techniques to quell it in the July issue of JCRS (37:1199-1207). “The most important thing about ND is that it only occurs with the lens in the bag,” Dr. Masket explained. “It can occur with any lens in the bag. I think it’s still controversial whether some lenses are more prone than others. People often point to the AcrySof lens [Alcon, Fort Worth, Texas, USA/Hünenberg, Switzerland] as being significantly causal, but they overlook the fact that more than half the lenses implanted in the world are the AcrySof lens.” Patient patterns Just as no one fully understands why ND occurs, doctors are unable to anticipate who will become symptomatic. Drs. Masket and Miller have picked up on a couple of trends, but evidence is antidotal for now. “When we look at the demographics of patients with this condition, there is kind of a blip on the screen where there will be more women in their 50s than any other gender or age group,” Dr. Masket said. “I won’t say that’s hard data, but that’s pretty much what we see. It’s odd. It hasn’t been carefully analyzed.” Dr. Miller notices a comparable personality thread throughout his ND patients. “I think the pattern is the more observant the patient, the more technical she is, the more engineer- like, the more she is likely to notice it,” he said. In terms of who won’t become symptomatic, Dr. Davison hasn’t seen ND in patients who are extremely nearsighted. Dr. Masket has never had an ND complaint from a child, although he hasn’t done a large number of pediatric cataract cases. He also stressed ND has never been reported in a sulcus- placed lens or with an anterior chamber lens. “The only thing I’ve proven clinically is if you take the lens out of the bag, the problem goes away,” Dr. Masket said. Solutions Luckily, most cases of ND fade with time and rarely need surgical intervention. If ND is going to dissipate on its own, it will be in the first 6 months. But it doesn’t always. A handful of patients will remain symptomatic a full year later. Why ND diminishes in some patients and continues to plague others is a mystery. Likewise, no one knows for sure why ND clears up in the first place. Some surgeons believe the patient adapts to the phenomenon over time and stops noticing it as much. Dr. Miller, however, continued on page 35